Tramadol without prescription
Falls under an opioid agonist, Tramadol hydrochloride extended-release capsules are indicated in order to manage moderate to moderately severe chronic pain in adult patients who need around-the-clock treatment of their pain for an extended period of time. Tramadol Pain Reliever extended-release capsules are available in 100 mg, 200 mg and 300 mg strength.
Tramadol For Pain Dosing Considerations: Tramadol hydrochloride capsules are intended for once daily dosing in adult patients aged 18 years and older. The pills should be swallowed whole through liquid and should not be crushed, split, chewed, or dissolved. Chewing, crushing or splitting the pills could result in the uncontrolled delivery of tramadol, in overdose and death tramadol capsules. Avoid administering capsules at a dose exceeding 300mg daily. Avoid using tramadol hydrochloride capsules more than once a day or concomitantly together with certain other tramadol products.
Side Effects of Tramadol: The most commonly reported side effects of tramadol include:
- Dry mouth
Mechanism of Action: Tramadol capsules are centrally acting synthetic opioid analgesic. Although in what ways it acts is not completely specified, from animal tests, at least a couple of complementary mechanisms appear applicable: binding of parent as well as M1-metabolite to the µ-opioid receptors and a bit weak inhibition of the reuptake of serotonin and norepinephrine.
The activity of opioid is due to decreased affinity binding of the parent compound as well as higher affinity binding of the O-demethylated metabolite M1 to the µ-opioid receptors. In the animal models, M1 is specifically up to 6-times more potent than the tramadol in order to produce analgesia and 200-times more potent in the µ-opioid binding. The tramadol induced analgesia is specifically partially antagonized by the opiate antagonist naloxone in the multiple animal tests. The associate contribution of the tramadol as well as M1 to the human analgesia is dependent upon the plasma concentrations of the each compound.
Use of Tramadol in Specific Population:
Pregnancy: Use only in case the benefit outweighs risk to the fetus. Neonatal seizures and withdrawal syndrome, fetal death and stillbirth have reported.
Labor and Delivery: Tramadol crosses the placenta, and must be avoided in order to be used prior to or during labor unless the potential benefits outweigh the risks. The long term administration during pregnancy may be responsible for causing dependence and withdrawal symptoms in the newborn.
Nursing mothers: Effect on the child not evaluated. Use of tramadol hydrochloride capsules is not recommended.
Storage of Tramadol: Tramadol without prescription should be dispensed in a tight container. Store it at 25°C; excursions permitted to 15°C-30°C (59°F-86°F). Keep out of reach of children.
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